The objective of the present research work was to formulate and optimize the solid lipid nanoparticles of carvedilol by full factorial design. Solid lipid nanoparticles of carvedilol have been developed to enhance oral bioavailability and sustain release of carvedilol. A 32 factorial design was utilized to optimize the formulation where the concentration of lipid tripalmitin (X1) and concentration of surfactant poloxamer 188 (X2) were taken as independent variables. SLNs were prepared by hot homogenization followed by ultrasonication method. Prepared SLNs were evaluated for morphology, mean particle size, zeta potential and in vitro drug release. The mean particle size and zeta potential values are in range of 50–210 nm and 8 mV respectively. In vitro release studies were performed in phosphate buffer pH 6.8 with 30% PEG 400. Percent of drug released in 5h and 24h, t50% and diffusion exponent were taken as the dependent variables. Polynomial equations and response surface plots were generated for all dependent variables using multiple regression analysis. It was observed that both the factors had significant influence on all dependent variables studied (p<0.05). The results indicating that release of the drug was primarily influenced by concentration of tripalmitin.
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